Abstract: The regional and provincial differences of the development of express service in China were studied from the angle of geography. The effects of charge of express service, resident income, economic development level, transportation and population in different region on express service were analyzed. It is discovered that there is a significant imbalance of regional development in express service in China. The business volume of express delivery in the eastern part of China is much larger than the middle China, western of China, and the Northeast China. The difference of resident income and economic development level is the major reason which restricts the development of express industry. Furthermore, by applying the analysis tool of SPSS, this paper establishes the optimal regression model which indicates the relationship among all the elements in different areas, to analyze the factors that affect the regional difference of the development of express service.