Abstract: A method combining active and passive compensation based on Field-Programmable Gate Array (FPGA) is proposed to address the challenges of signal extraction caused by excitation field coupling in magnetic nanoparticle imaging (MPI). Compensation signals are generated using a lock-in amplifier and differential amplification circuit to mitigate excitation field coupling and recover particle signals. Experimental results show that the proposed compensation strategy effectively suppresses excitation field coupling, significantly restoring the fundamental frequency information of the particle signals. This method enhances the resolution and sensitivity of the MPI system and is of significant importance for the application and advancement of MPI technology.