Abstract: To explore the repair mechanism of the total alkaloid of Sophora Viciifolia (SVA) on injured Achilles tendon, SVA was used to treat the injured Achilles tendon of rats. The effect of SVA on the repair of Achilles tendon injury was analysed by Achilles functional index (AFI) and histological evaluation score. The results showed that SVA treatment significantly increased AFI in rats, and histological observation score showed that the formation of granulation tissue, adhesion and scar were reduced in the SVA treatment group. Hematoxylin-eosin (H&E) staining showed that inflammatory cell infiltration was reduced in the SVA treatment group, and Masson staining proved that the SVA treatment group contained more collagen fibers than the control group, as well as immunofluorescence and molecular docking experiments confirmed that SVA could inhibit the high expression of inflammation and angiogenesis markers of injured Achilles tendon, and the effect of adding SVA on the 14th day after injury was better than that on the 7th day. It is demonstrated that SVA promotes the repair of injured tendons by regulating inflammation and angiogenesis signaling pathways.