The Preparation of Arb-BSA-NP Nanoparticals and Their Application to Burn Injury Repair

LIN Xiaoxia; HE Yingchang; YOU Rong

doi:10.6054/j.jscnun.2021076

Journal of South China Normal University (Natural Science Edition) > 2021 > 53(5): 62-67. > DOI: 10.6054/j.jscnun.2021076

LIN Xiaoxia, HE Yingchang, YOU Rong. The Preparation of Arb-BSA-NP Nanoparticals and Their Application to Burn Injury Repair[J]. Journal of South China Normal University (Natural Science Edition), 2021, 53(5): 62-67. DOI: 10.6054/j.jscnun.2021076

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The Preparation of Arb-BSA-NP Nanoparticals and Their Application to Burn Injury Repair

School of Life Sciences, South China Normal University, Guangzhou 510631, China

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Received Date: October 04, 2020
Available Online: November 10, 2021

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Abstract

Abstract

Bovine serum albumin V(BSA) was used as the carrier to prepare arbutin(Arb)-loaded nanoparticles (Arb-BSA-NP)with the desolvation method and the curative effect of Arb-BSA-NP on rat burn injury was studied. The particle size distribution and Zeta potential analysis were performed to characterize Arb-BSA-NP, and the results showed that the average particle size of Arb-BSA-NP was 175.26±11.04 nm and the average Zeta potential was -29.12±0.80 mV, which suggested that Arb-BSA-NP had a uniform particle size and good stability after 12 h of glutaraldehyde crosslinking under the conditions of pH7.0 and the ratio of arbutin to albumin was 1 : 10. Cellulose membrane was then immersed into the solution containing Arb-BSA-NPs, and the nanoparticles were precipitated onto the surface to form Arb-BSA-BC, which were manifested with the SEM analysis. The curative effect of Arb-BSA-BC on rat burn injury was attested with the burn repair experiment. It was proved that Arb-BSA-BC contributed to the repair and healing of burn injury.
- arbutin,
- Arb-BSA-NP,
- burn injury

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