YAO Q, XIE B Z, PEI Y H. Synthesis of Poly (ethylene glycol)-g-Polyethyleneimine-supported Superparamagnetic Iron(IV) Oxide nanoparticles and Its Application in Gene Delivery[J]. Journal of South China Normal University (Natural Science Edition), 2018, 50(6): 48-53. DOI: 10.6054/j.jscnun.2018116
Citation:
YAO Q, XIE B Z, PEI Y H. Synthesis of Poly (ethylene glycol)-g-Polyethyleneimine-supported Superparamagnetic Iron(IV) Oxide nanoparticles and Its Application in Gene Delivery[J]. Journal of South China Normal University (Natural Science Edition), 2018, 50(6): 48-53. DOI: 10.6054/j.jscnun.2018116
YAO Q, XIE B Z, PEI Y H. Synthesis of Poly (ethylene glycol)-g-Polyethyleneimine-supported Superparamagnetic Iron(IV) Oxide nanoparticles and Its Application in Gene Delivery[J]. Journal of South China Normal University (Natural Science Edition), 2018, 50(6): 48-53. DOI: 10.6054/j.jscnun.2018116
Citation:
YAO Q, XIE B Z, PEI Y H. Synthesis of Poly (ethylene glycol)-g-Polyethyleneimine-supported Superparamagnetic Iron(IV) Oxide nanoparticles and Its Application in Gene Delivery[J]. Journal of South China Normal University (Natural Science Edition), 2018, 50(6): 48-53. DOI: 10.6054/j.jscnun.2018116
In this work, amphiphilic copolymers were obtained by modifying hyperbranched polyethylenimine with methoxypolyethylene glycols. The utility of a multifunctional delivery vector comprised of antibody-polyethyloxide-polyethylenimine loaded with superparamagnetic iron oxide (Ab-PEG-PEI-SPIO) was investigated. The Ab-PEG-PEI-SPIO is capable of combining plasmid DNA into nanoparticles with diameters about 96nm (Ab-PEG-PEI-SPIO/pDNA complexes). The experiment results in vitro shows that the Ab-PEG-PEI-SPIO complexes transfect T-cells with high efficiency. The results of targeting group suggest that PEI-PEG possess the potential of combining application in gene delivery and MRI diagnosis.
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