The Myocardial Preservation Effect of Resveratrol by Up-Regulating GDF-15 to Activate PI3K/Akt/Bcl-2 Pathway in Acute Myocardial Infarction Rats

YAN Renliang; XIA Li; ZHOU Guohong; SHENG Xiaozhong

doi:10.6054/j.jscnun.2022029

Journal of South China Normal University (Natural Science Edition) > 2022 > 54(2): 76-82. > DOI: 10.6054/j.jscnun.2022029

YAN Renliang, XIA Li, ZHOU Guohong, SHENG Xiaozhong. The Myocardial Preservation Effect of Resveratrol by Up-Regulating GDF-15 to Activate PI3K/Akt/Bcl-2 Pathway in Acute Myocardial Infarction Rats[J]. Journal of South China Normal University (Natural Science Edition), 2022, 54(2): 76-82. DOI: 10.6054/j.jscnun.2022029

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The Myocardial Preservation Effect of Resveratrol by Up-Regulating GDF-15 to Activate PI3K/Akt/Bcl-2 Pathway in Acute Myocardial Infarction Rats

Guangdong Food and Drug Vocational College, Guangzhou 510520, China

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Received Date: May 12, 2021
Available Online: May 11, 2022

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Abstract

Abstract

To investigate the mechanism of resveratrol protecting myocardial ischemia, the rat myocardial ischemia-reperfusion (I/R) model was prepared with ligation and reperfusion of the anterior descending coronary artery. The serum enzyme indexes were analyzed with the kits, myocardial infarction rates were measured with NBT staining, and the western blotting method was used to investigate the relative protein expression levels of GDF-15, PI3K, Akt, p-Akt, Bcl-2, Bax, caspase-9 and caspase-3. The results showed that the myocardial protective effect of resveratrol on myocardial ischemia-reperfusion rats was related to the upregulation of GDF-15 to activate PI3K/Akt signaling pathway and inhibit cardiomyocyte mitochondrial apoptosis.
- resveratrol,
- ischemia-reperfusion,
- growth differentiation factor-15,
- PI3K,
- Akt

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The Myocardial Preservation Effect of Resveratrol by Up-Regulating GDF-15 to Activate PI3K/Akt/Bcl-2 Pathway in Acute Myocardial Infarction Rats

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