Abstract: With the bibliometric method and the scientific knowledge graph analysis method, the research literature on GIS-based cultural geography in the Web of Science database is screened, the knowledge graph of authors, disciplines and keywords is drawn through the CiteSpace visualization software, and then the core literature is traced to focus on the hot research topics. The findings are as follows. First, the literature of high centrality and prominence focuses on criticizing GIS, historical GIS and qualitative GIS. Second, the core literature mainly adopts the hierarchical color setting mode of ArcMAP mapping and the kernel density analysis to present the cartographic visualization of cultural geographic information. Third, the GIS-based cultural geography research has interdisciplinary advantages and good research prospects. In the future, cultural geography research can rely on open geographic information technology platforms such as the voluntary geographic information system for data acquisition and try more accurate spatial analysis methods such as spatial interpolation.