Abstract: Based on the differences of economic function, the economic system of the Chang Zhu Tan 3+5 urban agglomeration is divided into the production subsystem, the circulation subsystem, the distribution subsystem and the consumption subsystem. On the basis of the related system entropy, coupling degree, coupling coordinative degree and order parameter, the spatio-temporal differentiations of the urban agglomerations economic system is depicted and the rationality of the systems evolution is analyzed. The conclusions of the study are as follows. Firstly, the development and extension of the consumer market has played a dominant role in promoting the synergic development of the economic system of the Chang Zhu Tan 3+5 urban agglomeration. Secondly, the rapid improvement of transportation nets has strengthened the whole regions negotiability. For the core cities, the circulation subsystem tends to rationalize, but for the peripheral cities, the development has increased their burden. Thirdly, the consumption of the urban agglomeration is a little weak, but its development potential is strong.