金雀异黄素∕壳聚糖微球的制备及其释药性能

STUDY ON PREPARATION OF GENISTEIN-CHITOSAN MICROSPHERES AND THEIR DRUG—RELEASING PERFORMANCES

摘要: 制备了金雀异黄素/壳聚糖微球，考察了其理化性质和药物的缓释性能．结果表明，所得微球形状较规整，平均粒径2～4μm，载药质量分数为10.5%，药物包封率达质量分数52.5%．金雀异黄素以无定形聚集态分散在微球内部．微球中的药物有较好的缓释效果，而释药速率随投料比（药物/壳聚糖）的增大而增大，随反应介质pH的增大而增大．药物在酸性缓冲环境中的释药速率大于碱性缓冲环境中的释药速率．

Abstract: By using genistein as the model drug, genistein-chitosan microspheres were prepared by emulsion and cross-linking techniques with glutaraldehyde as a cross-linking agent.The physicochemical properties and the drug-release performances of the microspheres were investigated. The microspheres have a spherical shape and an average diameter about 2~4μm. The drug loading efficiency is 52.5% and the content of the drug is 10.5%. With the increase of pH of the reaction media or the concentration of genistein, the rate of releasing genistein increased. The result indicated that the microspheres have a satisfactory performance of slowly releasing the drug of genistein.