STUDY ON PREPARATION OF GENISTEIN-CHITOSAN MICROSPHERES AND THEIR DRUG—RELEASING PERFORMANCES

By using genistein as the model drug, genistein-chitosan microspheres were prepared by emulsion and cross-linking techniques with glutaraldehyde as a cross-linking agent.The physicochemical properties and the drug-release performances of the microspheres were investigated. The microspheres have a spherical shape and an average diameter about 2~4μm. The drug loading efficiency is 52.5% and the content of the drug is 10.5%. With the increase of pH of the reaction media or the concentration of genistein, the rate of releasing genistein increased. The result indicated that the microspheres have a satisfactory performance of slowly releasing the drug of genistein.