Carbon Nano-fragments and Nickel Glass Carbon Electrode for the Electrochemical Detection of Nifedipine

Carbon nano-fragments-nickel (CNF-Ni) composites were synthesized by sol-gel thermal reduction method for the modification of glassy carbon electrodes and applied in the electrochemical sensor construction of nifedipine. The morphology and catalytic characteristic of CNF-Ni/GCE electrode were studied employing field emission scanning electron microscope, X-ray diffraction, fourier infrared spectrometer, and electrochemical technology. The results indicated that CNF-Ni/GCE electrode exhibited favourable electrocatalytic performance for nifedipine determination. Under the optimal conditions, using differential pulse voltammetry (DPV), the linear relationship between anode peak current and nifedipine concentrations was obtained from 4 to 160 μmol/L, and the detection limits was 2 μmol/L. The proposed method was employed to determine nifedipine in the actual drug detection.