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过硫酸氢钾微球的制备、缓释及灭菌性能

杨远廷 吴紫倩 程文科 李芷晴 冷淑珍 陈铧耀 舒绪刚

杨远廷, 吴紫倩, 程文科, 李芷晴, 冷淑珍, 陈铧耀, 舒绪刚. 过硫酸氢钾微球的制备、缓释及灭菌性能[J]. 华南师范大学学报(自然科学版), 2021, 53(5): 46-52. doi: 10.6054/j.jscnun.2021074
引用本文: 杨远廷, 吴紫倩, 程文科, 李芷晴, 冷淑珍, 陈铧耀, 舒绪刚. 过硫酸氢钾微球的制备、缓释及灭菌性能[J]. 华南师范大学学报(自然科学版), 2021, 53(5): 46-52. doi: 10.6054/j.jscnun.2021074
YANG Yuanting, WU Ziqian, CHENG Wenke, LI Zhiqing, LENG Shuzhen, CHEN Huayao, SHU Xugang. Preparation, Release and Bactericidal Properties of Peroxymonosulfate Microspheres[J]. Journal of South China normal University (Natural Science Edition), 2021, 53(5): 46-52. doi: 10.6054/j.jscnun.2021074
Citation: YANG Yuanting, WU Ziqian, CHENG Wenke, LI Zhiqing, LENG Shuzhen, CHEN Huayao, SHU Xugang. Preparation, Release and Bactericidal Properties of Peroxymonosulfate Microspheres[J]. Journal of South China normal University (Natural Science Edition), 2021, 53(5): 46-52. doi: 10.6054/j.jscnun.2021074

过硫酸氢钾微球的制备、缓释及灭菌性能

doi: 10.6054/j.jscnun.2021074
基金项目: 

广东省科技计划项目 2017A040405055

详细信息
    通讯作者:

    舒绪刚,Email: xgshu@21cn.com

  • 中图分类号: X703;TU991.25

Preparation, Release and Bactericidal Properties of Peroxymonosulfate Microspheres

  • 摘要: 为提高过硫酸氢钾(KHSO5)的稳定性和减缓其有效成分的下降速度,以KHSO5复合盐为原料,采用挤出滚圆法制备骨架丸芯,进一步包膜为缓释微球;以累计释放率为考察指标,通过单因素进行工艺优化. 结果表明:当聚乙二醇-6000质量分数为35%、KHSO5复合盐质量分数为30%、阻滞剂为0.05 g/mL、致孔剂为0.003 g/mL和脂溶性膜为7层时,微球成膜性良好,形态较圆整且具有明显的膜孔;12 h内累计释放率达95.39%,符合Higuchi释药模型,释药机制以Fick扩散为主;对大肠杆菌和金黄色葡萄球菌的有效杀菌质量浓度均为2.0 g/L.
  • 图  1  KHSO5微球的SEM图及EDS能谱

    Figure  1.  The SEM images and EDS spectrum KHSO5 microspheres

    图  2  聚乙二醇-6000质量分数对KHSO5微球累计释放率的影响

    Figure  2.  The effect of PEG-6000 content on cumulative release of KHSO5 microspheres

    图  3  KHSO5复合盐质量分数对KHSO5微球累计释放率的影响

    Figure  3.  The effect of KHSO5 compound salt content on cumulative release of KHSO5 microspheres

    图  4  阻滞剂乙基纤维素质量浓度对KHSO5微球累计释放率的影响

    Figure  4.  The effect of ethyl cellulose content on cumulative release of KHSO5 microspheres

    图  5  脂溶性膜层数对KHSO5微球累计释放率的影响

    Figure  5.  The effect of lipid soluble membrane layers on cumulative release of KHSO5 microspheres

    图  6  致孔剂聚乙二醇-2000质量浓度对KHSO5微球累计释放率的影响

    Figure  6.  The effect of PEG-2000 content on cumulative release of KHSO5 microspheres

    图  7  KHSO5微球的缓释拟合曲线

    Figure  7.  The curves of slow release fitting of KHSO5microspheres

    图  8  KHSO5微球及KHSO5混合物对大肠杆菌、葡萄球菌的定性灭菌性能

    Figure  8.  The qualitative sterilization performance of KHSO5 microspheres and KHSO5 mixture against Escherichia coli and Staphylococcus aureus

    表  1  中和剂的选择试验结果

    Table  1.   The test results of selection of additives  cfu/mL

    组别 大肠杆菌的菌数 葡萄球菌的菌数
    1 0 0
    2 9.70×105 9.76×105
    3 1.04×106 2.03×106
    4 1.10×106 2.11×106
    5 1.52×106 2.33×106
    6 0 0
    下载: 导出CSV

    表  2  KHSO5微球与KHSO5混合物对细菌的定量灭菌性能

    Table  2.   The results of quantitative killing test of microspheres and peroxymonosulfate mixture against strains

    消毒剂 菌株 不同质量浓度消毒剂的杀菌率/%
    2.6 g/L 2.4 g/L 2.2 g/L 2.0 g/L 1.8 g/L 1.6 g/L
    KHSO5微球 大肠杆菌 100.00 100.00 100.00 99.91 95.62 92.35
    金黄色葡萄球菌 100.00 100.00 100.00 99.96 96.34 93.78
    KHSO5混合物 大肠杆菌 100.00 100.00 100.00 99.98 96.87 93.32
    金黄色葡萄球菌 100.00 100.00 100.00 100.00 97.64 94.68
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-03-12
  • 网络出版日期:  2021-11-11
  • 刊出日期:  2021-10-25

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