Abstract: According to the patent measurement , this paper evaluates the technological innovation synergism of Guangdong and One Belt and One Road Initiatives provinces, and puts forward some policy inspirations. Research findings: since 2000, the number of collaborative patent applications has been on the increase; of all the provinces, Shanghai has an absolute advantage, followed by Chongqing and Zhejiang; C (Chemistry, metallurgy) is the absolute advantage in the field of technology, and since 2007, the technological innovation capability has not been sustained, the technology update has been slow, and the characteristics of new technologies have declined; enterprise is the main force to participate in technological innovation cooperation, and plays a leading role, universities are active participants; the mainly kinship of technological innovation synergism are Margin Type, Comprehensive Type, Learning Edge Type and Geo Type. We shall encourage the enterprises in different provinces along The Belt and Roadto set up subsidiaries, combining collaborative agents and main coordination models; encourage the universities and research institutes to set up local research institutes actively and participate in the cooperation of production.