Abstract: Nanoscale zero valent iron (nZVI) could effectively remove of metronidazole (MNZ), however, the problem of low?mineralization?rate was still existence. In this study, nZVI was synthesized and the effect of H2O2 dosage on the removal of metronidazole and total organic carbon (TOC) were investigated. It was shown that the removal rate of metronidazole was further accelerated in the presence of both nZVI and H2O2, and the removal rate of TOC was obviously increased with the increase of H2O2 concentration. When the dosage of H2O2 was 0.55 g/L, the removal rate of TOC was 45.87%, which was nearly 18 times higher than that of nZVI alone. At the same time, the removal rate and the TOC removal rate of metronidazole in nZVI/H2O2 system were higher than those in the Fenton (Fe2+/H2O2 system), which were nearly 1.5 times and 7.1 times respectively. Therefore, The?synergism of hydrogen?peroxide and nanoscale zero-valent iron, not only strongly facilitating the removal rate of metronidazole, but also can effectively improve the mineralization rate of organic matter.