Abstract: This article is to assess the influence of SAK-HV given by gavage on blood lipid and oxidative stress in hyperlipidemia model rats and to investigate the possible mechanism of lowering cholesterol. Male Wistar rats were fed by high-fat diet for 10 weeks to build hyperlipidemia model rats. Then the model rats were randomly assigned to model group, NaHCO3 group, treatment (SAK-HV) group and positire control (atorvastatin) group by body weight and administrated with drugs perorally. 6 weeks later, all rats were anesthetized. Serum, aortas, intestines and livers were separated and analyzed. Data showed that compared to model group, the level of triglyceride and total cholesterol in serum of SAK-HV group were significantly reduced; fat deposition in liver was improved; the expression of NPC1L1 in intestine was inhibited and the expression of ABCG5/ABCG8 in liver was enhanced; the content of ROS in aorta was significantly reduced; the activity of SOD in serum was significantly improved; the content of MDA in serum was significantly decreased. These results demonstrated that SAK-HV could reduce the content of blood lipid, the level of body oxidative stress and the total cholesterol via inhibiting cholesterol intake in intestine and enhancing the excretion of cholesterol in liver. SAK-HV may be a promising candidate drug against hyperlipemia.