利用相位差分技术改善光学相干层析图像质量

Using Phase-Differential Technology to Improve the Imaging Quality of Optical Coherence Tomography

摘要: 针对光学相干层析成像（OCT）信号中的各种噪声项的干扰和微弱散射信号提取的困难，提出基于相位差分的光学相干层析成像（PD-OCT）. 首先利用相干参考臂中的纳米微调平台作为相位调制器获得相位调制参考光，然后光结合振镜扫描技术和CCD光谱采集的光谱相干层析技术（SDOCT），实现光学相干层析的相位差分成像.结果表明：相位差分技术可以准确实现青鳉鱼样品光学相干层析中的相位差分成像，弱散射信号增强337 dB,信噪比（SNR）增强58 dB，获得成像物体高信噪比的弱散射信号.

Abstract: To decrease the noise and to enhance the weak scattering signal, phase-differential optical coherence tomography (PD-OCT) for obtaining high signal to noise ratio (SNR) optical coherence tomography (OCT) is presented. A nano displacement platform in reference arm is designed to achieve the different phase of reference light. Combining with spectral domain optical coherence tomography technology, the phase-differential optical coherence tomography is obtained. Through experiments, vivo biological sample Oryzias minutillus is measured on this system. The results show that PD-OCT can decrease noise and improve weak scattering signal in SDOCT. The weak scattering signal enhancement is 337 dB. The SNR enhancement is 58 dB.