Abstract: In order to support the inter-domain handoff for wireless Mesh Network, an efficient seamless inter-domain handoff for wireless Mesh Network is proposed. The technology uses seamless handoff to reduce the handoff time delay. By binding the IP address with the STA physical address, address mapping table and routing algorithm in STA are designed. In order to realize the effective inter-domain handoff in wireless Mesh Network, the buffering strategy is built between source MAP and target MAP and the communication data package is kept during the handoff process. By employing the buffering strategy of network devices and the new path searching algorithm, the pressure during switching for STA and the package lose rate is reduced, and the seamless and quick switching inter-domain handoff for wireless Mesh Network is realized.