As a novel display device, electronic paper has been widely used in various fields; however, the electronic paper driving system still needs to be further improved for the better performance. During the driving process, the electrophoretic display (EPD) screen has no fixed threshold voltage value for gray scale display. Therefore, a driving scheme is required for displaying a specific gray scale. DC balance is a very important influence factor for display screens, and it could damage the screen and then influence the display life time if the DC had not been unbalanced. In this paper, two kinds of driving schemes are proposed based on DC balance. One driving scheme is to achieve DC balance during the gray scale circulation. The other is to achieve DC balance based one single gray scale transformation. Experimental results show that the proposed methods in this paper show good performance on commercial E-ink EPD devices.