Abstract: This paper analysis the evolution characteristics of different forms in the same industry environment, summarizes the competition and collaboration relationships between them, and determines the impact of these relationships on organizational evolution in manufacturing, then we propose countermeasures and suggestions which is conducive to the sustainable development of Guangzhou's producing industry. By using the population density dependency theory of organizational ecology and time-varying variables Cox model, the basic conclusions are achieved: (1) From 2000 to 2012, population density of Guangzhou manufacturing industry was positively related to the risk of the populations death; (2) Organizations age has negative relationship with the risk of the populations death and inhibits the effect of the population density on tissue death; (3) In the same age level, the risk of death that diversified enterprises are facing is greater than that of specifically oriented enterprises, but with organizations age increasing, the gap of the risk of death between them is growing; (4) The effect of the population density on foreign enterprises in risk of death is greater than the impact on domestic enterprises. But once being survived, with organizational age increasing the risk of death of foreign enterprises is basically the same as that of the domestic enterprises; (5) The influence of the population density on non-labor-intensive enterprises in the mortality risk is greater than that of labor-intensive enterprises.