Abstract: The prescribed thermodynamic function and surface thermodynamic function of nanomaterials are intrinsic functions of materials, which are closely related to the catalysis and adsorption properties of materials. Therefore, it is of great significance to accurately obtain the surface thermodynamic functions of real systems by using scientific technical methods. Because of its unique advantages such as simple operation, high sensitivity and no hypothetical conditions, the method of dissolution thermodynamics is more scientific than other methods. In this paper, the conductivity of AgBr nanoparticles in aqueous solution is measured, and the equilibrium constants of the nanomaterials are calculated in combination with the theory of dissolution thermodynamics. The dissolution thermodynamic functions, surface thermodynamic functions, partial molar surface thermodynamics and prescribed thermodynamic functions of nano-sized AgBr were obtained by using bulk materials as the comparison standard. This work provides physical and chemical parameters for the application of nanometer AgBr in the fields of photosensitivity catalysis adsorption and so on. This method has important guiding significance in predicting the properties of insoluble salt nanomaterials such as dissolution catalysis adsorption and so on.