自闭谱系障碍的大脑功能性连接研究进展

Research Progress of Functional Connectivity of Autism Spectrum Disorder

  • 摘要: 自闭谱系障碍是一种以早期社会交往上的广泛性异常、缺乏与人进行沟通的能力、异常局限的兴趣以及刻板重复性行为为特征的复杂的神经发育障碍.自闭谱系障碍的大脑功能性连接研究表明,自闭谱系障碍存在着大脑功能性连接的显著降低,这种神经同步性活动的异常与自闭谱系障碍的社交和沟通障碍的严重程度呈负相关.实验研究采用功能性近红外光谱成像技术,对自闭谱系障碍儿童静息状态下大脑皮层的功能性连接性进行测量,结果发现,自闭谱系障碍儿童的额叶和颞叶左右半球之间的功能性连接是显著降低的,而额叶和颞叶在语言加工和社会认知过程中起着重要作用.功能性近红外光谱成像技术作为一种光学脑成像技术,能够有效且可靠地揭示自闭谱系障碍的大脑异常功能性活动.

     

    Abstract: The research progress on the functional connectivity of autism spectrum disorder is illustrated. Autism spectrum disorder is an early-onset neurodevelopmental disorder characterized by the communication and social interaction impairments, repetitive and stereotyped behavior and restricted interests. The recent research finds that autistic adolescents and adults show the functional underconnectivity in the brain areas and this lower synchronization of neural activity has a negative correlation with the severity of symptoms in autism spectrum disorder. The functional near-infrared spectroscopy, a newly developed noninvasive optical neural imaging, is used to study autistic children between 8-11 years of age on the resting-state. The results indicate that, compared with typically developing children, autistic children show significantly lower functional connectivity in the bilateral inferior frontal cortices and temporal cortices. This functional underconnectivity has a negative correlation with the severity of language and communication and social interaction deficits of autism spectrum disorder. This study supports the feasibility and convenience of using the functional near-infrared spectroscopy method to assess atypical functional connectivity of cortical activity in autistic children and its potential for early diagnosis on autism spectrum disorder.

     

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