Abstract: A good water-soluble fluorescence probe 8-dansyl-aminoquinoline (DK) was synthesized and characterized. The probe showed fluorescence recognition and detection to copper (Ⅱ) or mercury (Ⅱ) ions in aqueous solutions. Upon the addition of Cu2+ and Hg2+, the fluorescent emission intensity of the probe was quenched. Other metal ions did not show similar recognition signals at the same condition. The molecule is a fluorescence probe with selectivity toward Cu2+ and Hg2+.