Abstract: Abstract Three new compounds 1， 2 and 3 have been synthesized by Perkin-type condensation reaction. The crystal structures of compounds 1 and 2 were determined by X-ray single crystal diffraction. The experimental results show the following results. The compound 1， (E)-2-2'-(1''-acetyl-1H-indol-3''-yl)vinyl-quinolin-8-yl acetate， belongs to the monoclinic， space group P2(1)/c with unit cell parameters a＝2.26566(9) nm， b＝2.01990(8) nm， c＝0.79445(3) nm， ＝90， ＝90.715(2) ， ＝90， V＝3.6354(2) nm3， Z＝8， Dc＝1.353 Mg/m3， ＝0.091 mm-1， F(000)＝1552， R1＝0.0526 and wR2＝0.1409. The compound 2， 1，1-Diacetoxy-1-(3'-benzo bthinophene)methane， belongs to the orthorhombic， space group Pccn with with unit cell parameters a＝1.70116(8) nm， b＝2.00171(8) nm， c＝0.76628(3) nm， ＝90， ＝90， ＝90， V＝2.60936(19) nm3， Z＝8， Dc＝1.345 Mg/m3， ＝0.251 mm-1， F(000)＝1104， R1＝0.0342 and wR2＝0.0985. The formation of compounds 1，2 and 3 show that the acidity in the Perkin type reaction will result in 1，1-diacetate formation and reduce the yield of condensation products.