检测了尖顶羊肚菌胞外多糖提取物对超氧阴离子、羟基自由基及ABTS自由基的抑制作用，评价体外抗氧化活性，用其灌胃衰老模型小鼠，观察其对小鼠大脑超氧化物歧化酶活性、脂褐素和丙二醛含量的影响。结果表明：2mg/mL 的尖顶羊肚菌胞外多糖提取物对超氧阴离子的抑制率为43.06%，1mg/mL的尖顶羊肚菌胞外多糖提取物对羟基自由基的抑制率为72.40%， 0.1mg/mL的尖顶羊肚菌胞外多糖提取物对ABTS自由基的抑制率为77.43%；50 mg/kg?d 的尖顶羊肚菌胞外多糖提取物能使雄性、雌性小鼠脑SOD活性分别提高20.70%、21.13%， LF含量分别降低35.14%、46.93%，MDA含量分别减少15.10%、15.61%。表明尖顶羊肚菌胞外多糖提取物具有良好的抗氧化和延缓衰老作用，对雌性小鼠延缓衰老效果略优于对雄性小鼠.延缓衰老作用，其延缓衰老的效果具有性别的差异，对雌性小鼠延缓衰老效果略优于对雄性小鼠.
Inhibitions of the exopolysaccharide extract from Morchella conica on superoxide anion, hydroxyl radical and ABTS free radical were tested for evaluating the in-vitro-antioxidant activity. And through gastric perfusion to aging model mice, effects of the extract on superoxide dismutase activity, content of malondialdehyde and lipofuscin in brains of mice were studied. The results showed that the exopolysaccharide extract inhibited superoxide anion by 43.06% at 2mg/ml, scavenged hydroxyl radical by 72.4% at 1mg/ml and ABTS free radical by 77.43% at 0.1mg/ml. And at 50 mg/kg?d of the extract, SOD activities of male and female mice were increased by 20.70% and 21.13% respectively, while contents of LF and MDA were decreased 35.14% and 46.93% , 15.10% and 15.61% . It suggests that the exopolysaccharide extract from M. conica has obviously antioxidative and antiaging effects,and had gender differences on the antiaging effects, expressing a superior effect on female mice.