以硫代水杨酸作为修饰剂，合成了水溶性的CdSe/ZnS纳米晶.合成最佳条件为: CdSe与包覆层ZnS摩尔比为1:8, pH值为11.00、回流时间为45 min、回流温度为80 0C.从透射电子显微镜看到该纳米晶外观是独特的树枝形；紫外吸收光谱和荧光光谱表明CdSe/ZnS纳米晶比单一的CdSe纳米晶具有更好的发光特性；荧光强度在3个月内变化不大.在最佳实验条件下，将合成的CdSe/ZnS与牛血清白蛋白（BSA）作用，测得体系相对荧光强度与BSA浓度呈线性关系，线性响应范围为2.56-15.0 mg L-1，线性方程为F=101.17C-11.29 (C为BSA浓度，单位是mg L-1),R＝0.9962，检出限为0.64 mg L-1.
The water-soluble CdSe/ZnS nanocrystals were synthesized using a small organic molecule with benzene ring (thiosalicylic acid) as modifier. The optical properties of CdSe and CdSe/ZnS were studied by fluorescence and UV-Vis absorption spectroscopy. The more remarkable enhancement of emision intensity for CdSe/ZnS nanocrystals was observed than for CdSe nanocrystals. The optimal conditions for synthesis are with a molar ratio of CdSe and ZnS of 1:8, pH 11.0 and refluxing for 45 min at 80 0C. The fluorescence intensity has been stable for 3 months. The shape of CdSe/ZnS nanocrystals showed unique dendritic structure under TEM. Under the optimal conditions, the fluorescent intensity in the system of CdSe/ZnS NCs-BSA is linearly proportional to the concentration of BSA from 2.56 to 15.00 mg L-1. The linear equation is F=101.2C-11.3(C, mg L-1), R＝0.9962, with a detection limit of 0.64 mg L-1.