Abstract: The enteric-soluble glycine ferrous pellets were prepared by using a polyacryli直接联系人：林羽，电话：15112022209，Emial：3159397414@qq.com 作者简介：舒绪刚，教授，主要从事食品和饲料添加剂研究，Email：xgshu@21cn.com 电话：13724001175c resin as an enteric coating material though means of a bottom spray. Using response surface methodology and orthogonal experiments to explore the optimal formulation and process parameters of enteric coating liquid,and characterized by FTIR, FIB-SEM and intelligent dissolution apparatus.The results showed that the ratio of the coating liquid was 1:1, the concentration of the coating liquid was 5.92 g/100 ml, and the concentration of the anti-adhesive agent was 3.13 g/100 ml, which reached 96% release in the simulated intestinal juice environment. When the fan frequency is 17 Hz, the liquid supply speed was 8 r/min, and the material temperature was 43 ℃, the coating operation reaches a complete rate of 96.7% at 0.5 h. FTIR analysis showed that the pharmacophore structure of the pellets was complete. FIB-SEM observation showed that the pellets with 187.8 nm drug-loaded clothes, 38.8 nm coats, and 668.6 nm enteric coated.