探讨五味子改善去卵巢小鼠学习能力的有效化学部位及相关的作用途径.采用溶剂极性递增法萃取分离五味子的醇提物，小鼠卵巢摘除6w后灌胃同等剂量的五味子萃取物，三等分辐射式迷宫检测小鼠的行为习得能力，并测定小鼠海马乙酰胆碱酯酶的活性.结果显示，去卵巢使小鼠每日的正确反应率和达标率明显降低（P0.05, P0.01），且海马中AChE的活性降低（P0.05）；苯甲酸雌二醇 、五味子正丁醇萃取物及乙醇萃取物均能明显提高去卵巢小鼠的正确反应率和达标率（P0.05, P0.01），而苯甲酸雌二醇和五味子正丁醇萃取物显著提高去卵巢小鼠海马AChE的活性（P0.05, P0.01），提示五味子正丁醇萃取物及乙醇萃取物均能显著提高去卵巢小鼠的学习能力，其中五味子正丁醇萃取物的功效优于乙醇萃取物，可能是五味子改善学习记忆的主要有效部位，其作用的途径可能与胆碱能神经系统相关.
The effects of different extracts of Schisandra on behavioral learning in ovariectomized mice and the correlative mechanisms were studied by experiments. Different fractions of Schisandra alcohol extract were obtained with different polarities of solvents. Ovariectomized mice were orally given the different medication for 28d. The behavioral learning of mice were mensurated in Model MG-2 maze. AChE activity in hippocampus was determined by ultraviolet spectrometry. The behavioral learning of ovariectomized mice were impaired significantly and the activity of AChE was depressed in hippocampus compared with that of the control group. Schisandra n-butanol extract and ethanol extract both enhanced the behavioral learning ability of ovariectomized mice. The n-butanol extract significantly decrease the hippocampal activity of AChE in ovariectomized mice. The results indicated that the effect of Schisandra n-butanol extract was better than thar of the ethanol extract. The effective components of Schisandra on learning improvement was concentrated in the n-butanol extract, which might be contributed with the activity of AChE in hippocampus.