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光谱法研究泮托拉唑钠与牛血清白蛋白的相互作用

刘里 成飞翔

刘里, 成飞翔. 光谱法研究泮托拉唑钠与牛血清白蛋白的相互作用[J]. 华南师范大学学报(自然科学版), 2017, 49(1): 74-79.
引用本文: 刘里, 成飞翔. 光谱法研究泮托拉唑钠与牛血清白蛋白的相互作用[J]. 华南师范大学学报(自然科学版), 2017, 49(1): 74-79.
LIU L, CHENG F X. Study on the Interaction between Pantoprazole Sodium and Bovine Serum Albumin by Spectrometry[J]. Journal of South China normal University (Natural Science Edition), 2017, 49(1): 74-79.
Citation: LIU L, CHENG F X. Study on the Interaction between Pantoprazole Sodium and Bovine Serum Albumin by Spectrometry[J]. Journal of South China normal University (Natural Science Edition), 2017, 49(1): 74-79.

光谱法研究泮托拉唑钠与牛血清白蛋白的相互作用

基金项目: 

云南省教育厅科学研究基金项目;有限群的结构及 Fitting 类中一些问题的研究

详细信息
    通讯作者:

    刘里

Study on the Interaction between Pantoprazole Sodium and Bovine Serum Albumin by Spectrometry

  • 摘要: 在优化的实验条件下,运用荧光光谱法和紫外光谱法研究牛血清白蛋白(BSA) 与泮托拉唑钠(PS)的结合作用。研究表明:PS对BSA的荧光有猝灭作用,属于静态猝灭。BSA能运载PS,是一个自发过程,其作用力类型主要为氢键和范德华力。BSA 的亚螺旋域ⅢA是主要结合位置,离酪氨酸残基更近,有正协同作用。PS对BSA构象产生影响,使BSA腔内疏水环境的极性减弱。该实验对揭示药物动力学问题及后续抗菌类药物的研发提供了理论依据。
  • [1] 邱珲,杨庆云,童元峰,等.泮托拉唑钠单水合物与倍半水合物的晶型与稳定性差异研究[J].中国新药杂志, 2015,24(8):869.
    [2] Molina-Bolívar J.A., Galisteo-González F., Carnero Ruiz, C., et al.Interaction between the anti-cancer drug diacetyl maslinic acbovine serum albumin: A biophysical study[J]. Journal of Molecular Liquids,2015,208: 304.
    [3] Nahid Shahabadi, Saba Hadidi.Molecular modeling and spectroscopic studies on the interaction[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2014,122:100.
    [4] Dai Chunmei, Ji Cunwei , Lan Huixiang , et al .Study of the interaction between mercury (II) and bovine serum albumin by spectroscopic methods[J]. Environmental toxicology and pharmacology 2014,37:870.
    [5] Bogdam S. Fluorescence study of sinapic acid interaction with bovine serum albumin and egg albumin [J]. J. Flurescence, 2003,13(4) : 349-356.
    [6] Lakowicz, J. R. Principles of Fluorescence Spectroscopy 3rd ed.[M], Springer Press, New York, 2006, p. 285.
    [7] 许金钩,王尊本.荧光分析法(第三版)[M].北京:科学出版社, 北京, 2006: p. 23-49.
    [8]刘里,成飞翔.光谱法研究头孢替唑钠与牛血清白蛋白相互作用[J].江西师范大学学报(自然科学版) ,2014,38(6):639.
    [9] 刘里,成飞翔.光谱法研究洛索洛芬钠与牛血清白蛋白的相互作用及共存金属离子的影响[J].中国生化药物杂志,2014,35(1):21.
    [10] 刘保生,杨超,王晶.硫酸头孢匹罗与牛血清白蛋白结合反应的发光机理[J]. 发光学报,2011,32(3): 293-295.
    [11] Cyril, L.; Earl, J. K.; Sperry, W. M. Biochemists Handbook, Epon Led Press, London, 1961, 84.
    [12] Ross D P , Subramantan S. Thermodynamics of Protein Association Reactions : Forcrs Cont ributing to Stability [J] . Biochemstry , 1981 , 20(11): 3096 -3102.
    [13] Sulkowska A.,Maciazek-Jurczyk M.,Bojko B.,et al. Competitive binding of phenylbutazone and colchicine to serum albumin in multidrug therapy [J].J.Mol.Struct.,2008,881( 1-3) : 97-106.
    [14] Maciazek-Jurczyk M,Sulkowska A,Bojko B,et al. Fluorescence analysis of competition of phenylbutazone and methotrexate in binding to serum albumin in combination treatment in rheumatology [J].J.Mol.Struct.,2009,924-926: 378-384.
    [15] Xu H,Gao S L,Lv J B,et al. Spectroscopic investigations on the mechanism of interaction of crystal violet with bovine serum albumin [J].Mol. Struct.,2009,919( 1-3) : 334-338.

    [1] 邱珲,杨庆云,童元峰,等.泮托拉唑钠单水合物与倍半水合物的晶型与稳定性差异研究[J].中国新药杂志, 2015,24(8):869.
    [2] Molina-Bolívar J.A., Galisteo-González F., Carnero Ruiz, C., et al.Interaction between the anti-cancer drug diacetyl maslinic acbovine serum albumin: A biophysical study[J]. Journal of Molecular Liquids,2015,208: 304.
    [3] Nahid Shahabadi, Saba Hadidi.Molecular modeling and spectroscopic studies on the interaction[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2014,122:100.
    [4] Dai Chunmei, Ji Cunwei , Lan Huixiang , et al .Study of the interaction between mercury (II) and bovine serum albumin by spectroscopic methods[J]. Environmental toxicology and pharmacology 2014,37:870.
    [5] Bogdam S. Fluorescence study of sinapic acid interaction with bovine serum albumin and egg albumin [J]. J. Flurescence, 2003,13(4) : 349-356.
    [6] Lakowicz, J. R. Principles of Fluorescence Spectroscopy 3rd ed.[M], Springer Press, New York, 2006, p. 285.
    [7] 许金钩,王尊本.荧光分析法(第三版)[M].北京:科学出版社, 北京, 2006: p. 23-49.
    [8]刘里,成飞翔.光谱法研究头孢替唑钠与牛血清白蛋白相互作用[J].江西师范大学学报(自然科学版) ,2014,38(6):639.
    [9] 刘里,成飞翔.光谱法研究洛索洛芬钠与牛血清白蛋白的相互作用及共存金属离子的影响[J].中国生化药物杂志,2014,35(1):21.
    [10] 刘保生,杨超,王晶.硫酸头孢匹罗与牛血清白蛋白结合反应的发光机理[J]. 发光学报,2011,32(3): 293-295.
    [11] Cyril, L.; Earl, J. K.; Sperry, W. M. Biochemists Handbook, Epon Led Press, London, 1961, 84.
    [12] Ross D P , Subramantan S. Thermodynamics of Protein Association Reactions : Forcrs Cont ributing to Stability [J] . Biochemstry , 1981 , 20(11): 3096 -3102.
    [13] Sulkowska A.,Maciazek-Jurczyk M.,Bojko B.,et al. Competitive binding of phenylbutazone and colchicine to serum albumin in multidrug therapy [J].J.Mol.Struct.,2008,881( 1-3) : 97-106.
    [14] Maciazek-Jurczyk M,Sulkowska A,Bojko B,et al. Fluorescence analysis of competition of phenylbutazone and methotrexate in binding to serum albumin in combination treatment in rheumatology [J].J.Mol.Struct.,2009,924-926: 378-384.
    [15] Xu H,Gao S L,Lv J B,et al. Spectroscopic investigations on the mechanism of interaction of crystal violet with bovine serum albumin [J].Mol. Struct.,2009,919( 1-3) : 334-338.
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出版历程
  • 收稿日期:  2015-09-14
  • 修回日期:  2015-11-22
  • 刊出日期:  2017-02-25

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