叶剑敏, 王玉红, 丁明媚, 尹晓雪. 硬骨鱼IgM结构和功能及其体液免疫应答[J]. 华南师范大学学报(自然科学版), 2015, 47(5): 1-8.
引用本文: 叶剑敏, 王玉红, 丁明媚, 尹晓雪. 硬骨鱼IgM结构和功能及其体液免疫应答[J]. 华南师范大学学报(自然科学版), 2015, 47(5): 1-8.
Teleost IgM Structure, Function and Humoral Immune Response[J]. Journal of South China Normal University (Natural Science Edition), 2015, 47(5): 1-8.
Citation: Teleost IgM Structure, Function and Humoral Immune Response[J]. Journal of South China Normal University (Natural Science Edition), 2015, 47(5): 1-8.

硬骨鱼IgM结构和功能及其体液免疫应答

Teleost IgM Structure, Function and Humoral Immune Response

  • 摘要: 经典免疫学理论有2个基本模式阐述抗体免疫反应的发展和功能:(1)亲和力成熟依赖于机体本身的和通过突变形成的高亲和力抗体的抗原驱动选择过程;(2)抗体的生物效应功能是由抗体的类型所决定的.最近研究发现硬骨鱼的免疫系统通过调控结合抗原的亲和力大小来改变分泌的IgM抗体同质异构体结构的比例,从而影响其抗体在血清中的半衰期.这种独特性质的发现是对经典免疫学理论的补充和扩展.文章概述了硬骨鱼IgM抗体结构和功能的亲和力驱动调节,并介绍维持体液免疫记忆的长寿命浆细胞和记忆性B细胞的性质以及抗体分泌细胞(如原浆细胞、浆细胞)在体液免疫应答中的作用.了解硬骨鱼IgM结构和功能的关系,以及不同分化阶段B细胞维持体液免疫反应的机制,将有利于探索构建硬骨鱼免疫评价体系,并为高效的渔用疫苗开发和疫苗效果精确性评价奠定理论基础.

     

    Abstract: Two classical immunological paradigms have been operated to govern the development and functionality of the antibody response: (1)affinity maturation is primarily dependent upon antigendriven selection of both the germline and somatically amended high affinity repertoires, and (2) antibody effector function is isotypically determined. Recent findings, utilizing the teleost IgM model, suggest that these classical paradigms should be broadened to incorporate the ability of the immune system to transducer the strength of antigen recognition (affinity) into isomerism structural modification that, in turn, modulate the halflife of antibody in serum. More importantly, the discovery of teleost unique feature reveals a heretofore unknown level of sophistication by which the immune system can interpret and response to the antigenic universe. The aim of this paper is to introduce key findings of recent studies in the functional explanation and cellular regulation of the affinityinduced teleost IgM isomerism, the mechanisms of longlived plasma cells, shortlived plasma cells, plasmablasts and memory B cells on maintaining the teleost humoral immune response. Upon resolving the mechanisms of affinityinduced teleost IgM isomerism and its humoral memory response, more cogent vaccine designs could be effectively developed and more precise system to evaluate the protective efficiency of vaccines will be established.

     

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