刘聪, 李国明, 林跃, 骆小伟, 高回春, 刘星, 汪朝阳. 盐酸阿米替林/壳聚糖微球的制备[J]. 华南师范大学学报(自然科学版), 2008, 1(4): 81-86 .
引用本文: 刘聪, 李国明, 林跃, 骆小伟, 高回春, 刘星, 汪朝阳. 盐酸阿米替林/壳聚糖微球的制备[J]. 华南师范大学学报(自然科学版), 2008, 1(4): 81-86 .
Liu-cong, . Preparation of Amitriptyline Hydrochloride-Chitosan Microspheres[J]. Journal of South China Normal University (Natural Science Edition), 2008, 1(4): 81-86 .
Citation: Liu-cong, . Preparation of Amitriptyline Hydrochloride-Chitosan Microspheres[J]. Journal of South China Normal University (Natural Science Edition), 2008, 1(4): 81-86 .

盐酸阿米替林/壳聚糖微球的制备

Preparation of Amitriptyline Hydrochloride-Chitosan Microspheres

  • 摘要: 以一种三环类抗抑郁药盐酸阿米替林为模型药物,采用乳化分散-化学交联法,以乙二醇二缩水甘油醚(ethylene glycol diglycidyl ether,EGDE)为交联剂,制备了盐酸阿米替林壳聚糖微球,考察了其理化性质和释放性能.EGDE 两末端为环氧基团,与氨基反应生成-C-N-键从而起交联作用.所得微球球形规整,呈乳白色,释药速率随CS浓度增大而减慢,在酸性缓冲溶液中略大于碱性缓冲溶液中. 结果表明盐酸阿米替林-壳聚糖微球具有较好的药物缓释性能.

     

    Abstract: By using Amitriptyline Hydrochloride as the model drug,amitriptyline hydrochloride-chitosan microspheres were prepared by emulsion cross-linking techniques with ethylene glycol diglycidyl ether (EGDE) as a cross-linking agent. The physicochemical properties and the drug-release performances of the microspheres were investigated. EGDE has epoxy groups and cross-linking reaction occurred with the groups of -NH2 on CS. The microspheres have the color of white, a spherical shape and an average diameter about 12.32m. The drug loaded efficiency is 26.25% and the content of the drug is 6.56%(/). With the increase of the concentration of CS , the releasing ratio of Amitriptyline Hydrochloride decreases. The result indicated that the microspheres have a satisfactory performance of slowly releasing the drug of Amitriptyline Hydrochloride.

     

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