碳纳米碎片-镍修饰电极电化学检测硝苯地平的研究

Carbon Nano-fragments and Nickel Glass Carbon Electrode for the Electrochemical Detection of Nifedipine

    摘要
  • 摘要: 通过溶胶-凝胶热还原法制备碳纳米碎片-镍(CNF-Ni)复合材料，用于玻碳电极的修饰，构建硝苯地平电化学传感器(CNF-Ni/GCE)。通过扫描电子显微镜、X射线衍射、红外光谱和电化学技术研究CNF-Ni/GCE电极的形貌和催化特性。结果表明：CNF-Ni/GCE修饰电极对硝苯地平具有良好的催化性能。在优化实验条件的基础上，利用差分脉冲伏安技术测定，硝苯地平浓度在4~160 μmol/L范围内与其氧化峰电流呈良好的线性关系，检出限为2 μmol/L。该方法可用于实际药品中硝苯地平的检测。

     

    Abstract: Carbon nano-fragments-nickel (CNF-Ni) composites were synthesized by sol-gel thermal reduction method for the modification of glassy carbon electrodes and applied in the electrochemical sensor construction of nifedipine. The morphology and catalytic characteristic of CNF-Ni/GCE electrode were studied employing field emission scanning electron microscope, X-ray diffraction, fourier infrared spectrometer, and electrochemical technology. The results indicated that CNF-Ni/GCE electrode exhibited favourable electrocatalytic performance for nifedipine determination. Under the optimal conditions, using differential pulse voltammetry (DPV), the linear relationship between anode peak current and nifedipine concentrations was obtained from 4 to 160 μmol/L, and the detection limits was 2 μmol/L. The proposed method was employed to determine nifedipine in the actual drug detection.

     

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