The Preparation of Novel Bone-repair Materials of Gelatin-amorphous Calcium Phosphate through Three-dimensional Printing
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摘要: 首先采用共沉淀法制备明胶改性的无定形磷酸钙(ACP)粉末材料，再以纯水作为粘接溶液，通过3D打印机制造骨移植修复材料，并应用红外光谱仪、X射线衍射仪以及扫描电子电镜进行表征. 对于明胶稳定无定形磷酸钙化学结构的相关作用机制给出了初步的解释，重点考察了明胶添加量对打印骨成品的微观形貌、抗压强度以及孔隙率的影响规律，确定了明胶最佳用量为0.15%(质量分数)，此时打印骨成品的抗压强度高达31.7 MPa，孔隙率为30.2%，表明打印骨成品在力学性能和骨传导性之间取得了平衡，可被广泛应用于骨修复临床应用.Abstract: The amorphous calcium phosphate (ACP) modified by gelatin was prepared with the coprecipitation method and then used as prototyping powder for three-dimensional printing (3DP). The 3DP products of bone repair materials were fabricated with deionized water serving as adhesive solution and then characterized with Fourier transform infrared spectroscopy(FT-IR), X-ray diffraction (XRD) and scanning electron microscope (SEM) separately. The mechanism of ACP stabilized with gelatin was initially discussed and the effect of gelatin content on the chemical stability of ACP and the compressive strength as well as porosity of 3DP products were investigated respectively. The optimal dosage of gelatin was determined to be 0.15% (mass fraction) and the corresponding compressive strength and bone conductibility of the 3DP products were 31.7 MPa and 30.2% respectively, at which a balance was obtained between them and the 3DP products could be widely used for repairing bone defects.
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图 1 恒温恒湿条件下明胶-ACP的储存寿命
Figure 1. The storage lifetime of gelatin-ACP under constant temperature and humidity
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图 2 恒温恒湿保养10周后明胶-ACP的XRD图谱
Figure 2. The XRD patterns of gelatin-ACP stored 10 weeks under constant temperature and humidity
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