Abstract: Relay selection (RS) and power control are two essential parts in wireless relay network. RS is equal to power control in the condition that a relay cooperates with its full power or without any cooperation. Thus, the optimal signal-to-noise ratio (SNR) is interpreted as a 0-1 nonlinear programming integer problem (NLIP). A Glowworm Swarm Optimization (GSO) based multiple relay selection (MRS) scheme is proposed, which can fully obtain the optimal SNR value. Simulations results show that the proposed GSO-aided MRS scheme is superior to the conventional schemes, including the exhaustive search methods, single RS scheme and other suboptimal MRS schemes.