Abstract: A heavy metal-resistance bacterial strain MS1 was isolated from the Fankou Pb-Zn mine tailings in Guangdong Province. The minimum inhibiting concentrations of Pb2+ and Zn2+ to the strain were 4 and 40 mmol/L, respectively. Strain MS1 could grow at temperatures 17 ~37 ℃, pH 3~13 and high salinity conditions, with optimal conditions of temperature 27 ℃, pH 7.0 and 5% salinity. The maximum adsorption quantities and the maximum adsorption rates of strain MS1 to Pb2+ and Zn2+ were 13.9, 20.0 mg/g and 23.3%, 25.2% at 2 mmol/L Pb2+ and 10 mmol/L Zn2+ within 60h, respectively. The adsorption ability of strain MS1 to Zn2+ was greater than Pb2+. In a word, strain MS1 had strong resistance and adsorption ability to Pb2+ and Zn2+, and could be used to remediate heavy metal polluted water.